PREPRINTS
Unckless, RL, PA Lansdon and BD Ackley. 2020. A comparative analysis of Caenorhabditis and Drosophila transcriptional changes in response to pathogen infection. biorXiv: 977595. PDF
Gupta, Anjali, and Robert L. Unckless. "Autosomal suppression of meiotic drive can prevent sex chromosome cycling." bioRxiv (2023): 2023.09.28.559847. bioRxiv
Perlmutter, Jessamyn I. et al "Wolbachia enhances the survival of Drosophila infected with fungal pathogens." bioRxiv (2023): 2023.09.30.560320. PDF
Wei, K. H. C., C.-H. Chang, K. Chatla, A. Krishnapura, S. P. Appiah et al., 2023 Germline novelty through recurrent copy-number, protein, and regulatory evolution of the synaptonemal complex. bioRxiv: 2023-2010. bioRxiv
Mullinax, Sarah R. et al "A suite of selective pressures supports the maintenance of alleles of a Drosophila immune peptide." bioRxiv (2023): 2023.08.18.553899. PubMed
Unckless RL. Meiotic drive, postzygotic isolation, and the Snowball Effect. bioRxiv [Preprint]. 2023. 14:2023.11.14.567107. PDF
Prior publications
2024
Hernández, José Fabricio López et al "Modeling the Evolution of Populations with Multiple Killer Meiotic Drivers." G3: Genes, Genomes, Genetics (2024), jkae142. G3
Perlmutter, Jessamyn I. et al "A single amino acid polymorphism in natural Metchnikowin alleles of Drosophila results in systemic immunity and life history tradeoffs." Plos Genetics (2024) 20 (3), e1011155. PDF
2023
Schedl, M.E., Nguyen, N.H., Unckless, R.L., Perlmutter, J.I. Maintenance and Evaluation of Wolbachia Male-Killers of Dipterans. In: Fallon, A.M. (eds) Wolbachia. Methods in Molecular Biology (2024), vol 2739. Humana, New York, NY. Link
YM Alhammad, S Parthasarathy, R Ghimire, CM Kerr, JJ O’Connor, JJ Pfannenstiel, D Chanda, CA Miller, N Baumlin, M Salathe, RL Unckless, S Zuñiga, L Enjuanes, S More, R Channappanavar, AR Fehr. 2023. SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice. PNAS. Doi: 10.1073/pnas.2302083120 (link to PNAS)
KL Vertacnik, DK Herrig, RK Godfrey, T Hill, SM Geib, RL Unckless, DR Nelson, CR Linnen. 2023. Ecological correlates of gene family size in a pine-feeding sawfly genome and across Hymenoptera. bioRxiv. Doi: 10.1101/2021.03.14.435331. (PDF)
BR Smith, KB Patch, RL Unckless. 2023. The genetic basis of variation immune defense against Lysinibacillus fusiformis infection in Drosophila melanogaster. PLOS Pathogens. Doi: 10.1101/2022.10.19.512815. (link to PLOS Pathogens)
2022
W Ma, EM Knoles, KB Patch, MM Shoaib, and RL Unckless, 2021. Hoisted with his own petard: how sex-ratio meiotic drive in Drosophila affinis creates resistance alleles that limit its spread. Journal of Evolutionary Biology. Doi:10.1111/jeb.14077. (link to JEB)
RP Meisel, D Asgari, F Schlamp, and RL Unckless, 2021. Induction and inhibition of Drosophila X chromosome gene expression are both impeded by the dosage compensation complex. G3: jkac165. Doi: 10.1093/g3journal/jkac165. (link to G3)
CR Linnen, Y Brandvain, and RL Unckless. 2022. Theme: Recent work in speciation research by women authors. Evolution 76: 1100-1103. doi:10.1111/evo.14444. (link to Evolution)
ME Ochs, RM McWhirter, RL Unckless, DM Miller III, EA Lundquist. 2021. Caenorhabditis elegans ETR-1/CELF has broad effects on the muscle cell transcriptome, including genes that regulate translation and neuroblast migration. BMC Genomics: 23,1 13. doi:10.1186/s12864-021-08217-6. (link to BMC Genomics)
Hill, T, RL Unckless and JI Perlmutter. 2020. Positive selection and horizontal gene transfer in the genome of a male-killing Wolbachia. Molecular Biology and Evolution: 39: msab303. Doi: 10.1093/molbev/msab303. (link to MBE)
2021
Hill, T, HL Rosales-Stephens, and RL Unckless. 2021. Rapid divergence of the copulation proteins in the Drosophila dunni group is associated with hybrid post-mating-prezygotic incompatibilities. G3: 11:jkab050. PDF
Hill, T and RL Unckless. 2021. Adaptation, ancestral variation and gene flow in a ‘Sky Island’ Drosophila species. Molecular Ecology 30:83-99. doi: 10.1111/mec.15701. PDF
2020
Hill, T and RL Unckless. 2020. Recurrent evolution of two competing haplotypes in an insect DNA virus. bioRXiv: 10.1101/2020.0514.096024. eLife: e58931. doi: 10.7554/elife.58931. PDF
Price, TA, Windbichler, N, RL Unckless, et al. 2020. Resistance to natural and synthetic gene drive systems. Journal of Evolutionary Biology 33: 1345-1360. (link to Journal of Evolutionary Biology)
Bravo Nunez, MA, IM Sabbarini, LE Eide, RL Unckless and SE Zanders. 2020. Atypical meiosis can be adaptive in outcrossed S. pombe due to wtf meiotic drivers. eLife: 9:e57936. (link to eLife)
Chapman, JR, MA Dowell, R Chan and RL Unckless. 2020. The genetic basis of natural variation in Drosophila melanogaster immune defence against Enterococcus faecalis. Genes: 11:234. (link to Genes)
Unckless, RL and HA Orr. 2020. The population genetics of evolutionary rescue in diploids: X chromosomal vs. autosomal rescue. The American Naturalist: 195: 561-568. (link to The American Naturalist)
2019
Hanson, MA, B Lemaitre, and RL Unckless. 2019. Dynamic evolution of antimicrobial peptides underscores trade-offs between immunity and ecological fitness. Frontiers in immunology 10: 2620. (link to Frontiers)
Chapman, JR, T Hill and RL Unckless. 2019. Balancing selection drives the maintenance of genetic variation in Drosophila antimicrobial peptides. Genome Biology and Evolution: 11: 2691-2701. (doi: 10.1093/gbe/evz191) (link to GBE)
Hill, T and RL Unckless. 2019. A deep learning approach for detecting copy number variation in next generation sequencing. G3: Genes, Genomes, Genetics 9: 3575-3582. doi: 10.1534/g3.119.400596. (link to G3)
Benomar, S, KC Evans, RL Unckless and JR Chandler. 2019. Efflux pumps in Chromobacterium species increase antibiotic resistance and promote survival in a co-culture competition model. Appled and environmental microbiology: 85: e00908-19. doi: 10.1128/AEM.00908-19. (link to AEM)
Lea, JK and RL Unckless. 2019. An assessment of the immune costs associated with meiotic drive chromosomes in Drosophila. Proceedings of the Royal Society B. 286: 20191534 (doi: 10.1098/rspb.2019.1534) (link to PRSB)
Perlmutter, JI, SR Bordenstein, RL Unckless, DP LePage, J Metcalf, T Hill, J Martinez, FM Jiggins, SR Bordenstein. 2019. The phage gene wmk is a candidate for male killing by a bacterial endosymbiont. PLOS Pathogens 15(9): e1007936. (doi: 10.1371/journal.ppat.1007936) (link to PLOS Pathogens)
Hill, T, BS Koseva and RL Unckless. 2019. The genome of Drosophila innubila reveals lineage-specific patterns of selection in immune genes. Molecular Biology and Evolution Advanced access. doi: 10.1093/molbev/msz059 (link to MBE)
Zanders, SE and RL Unckless. 2019. Fertility costs of meiotic drivers. Current Biology 29:R512-R520. doi: 10.1016/j.cub.2019.03.046. (link to Current Biology)
Duxbury, EML, JP Day, DM Vespasiani, Y Thuringer, I Tolosana, SCL Smtih, L Tagliaferri, A KAacioglu, I Lindsley, L Love, RL Unckless, FM Jiggins and B Longdon. 2019. Host-pathogen coevolution increases genetic variation in susceptibility to infection. eLife 8: e46440. doi:10.7554/eLife.46440. (link to eLife)
2018
Pieper, KM, RL Unckless and KA Dyer. 2018. A fast-evolving X-linked duplicate of importin-a2 is overexpressed in sex-ratio drive in Drosophila neotestacea. Molecular ecology 27(24): 5165-5179. doi:10.1111/mec.14928.
Smith, BR and RL Unckless. 2018. Draft genome of Lysinibacillus fusiformis Strain Juneja, a laboratory-derived pathogen of Drosophila melanogaster. Genome Announcements 6(5), e01571-17. doi:10.1128/genomeA.01571-17.
Hill, T and R.L. Unckless. 2018. The dynamic evolution of the Drosophila innubila Nudivirus. Infection, Genetics and Evolution 57: 151-157. doi:10.1016/j.meegid.2017.11.013.
2017
Hill, T. and R.L. Unckless. 2017. 2017. Baculovirus molecular evolution via gene turnover and recurrent positive selection of key genes. Journal of Virology 91: e01319-17. doi: 10.1128/JVI.01319-17.
Ahmed-Braimah, Y.H., R.L. Unckless and A.G. Clark. 2017. Evolutionary dynamics of male reproductive genes in the Drosophila virilis subgroup. G3: Genes, Genomes, Genetics 2017;7(9):3145-55. doi:10.1534/g3.117.1136.
2016
Akhund-Zade, J., A.O. Bergland and R.L. Unckless. 2016. The genetic basis of natural variation in virgin egg retention in Drosophila melanogaster (Diptera: Drosophilidae). Journal of Insect Science 17(1). doi:10.1093/jisesa/iew094.
Lindholm, AK, … RL Unckless, et al. (22 authors). 2016. The ecology and evolutionary dynamics of meiotic drive. Trends in Ecology and Evolution 31:315-326. doi:10.1016/j.tree.2016.02.001.
Unckless, RL and BP Lazzaro. 2016. The potential for adaptive maintenance of diversity in insect antimicrobial peptides. Philisophical Transactions of the Royal Society B 371:20150291. doi: 10.1098/rstb.2015.0291.
Unckless, RL, VM Howick and BP Lazzaro. 2016. Convergent balancing selection on an antimicrobial peptide in Drosophila. Current Biology 26:257-262. Doi: 10.1016/j.cub.2015.11.063
2015
Unckless, RL and AG Clark. 2015. Driven to extinction: on the probability of evolutionary rescue from sex-ratio meiotic drive. bioRxiv doi: http://dx.doi.org/10.1101/018820.
Unckless, RL, PW Messer T Connallon and AG Clark. 2015. Modeling the Manipulation of Natural Populations by the Mutagenic Chain Reaction. Genetics 201:425-431. doi: 10.1534/genetics.115.177592 (Highlighted article).
Unckless, RL, SM Rottschaefer and BP Lazzaro. 2015. The Complex Contributions of Genetics and Nutrition to Immunity in Drosophila melanogaster. PLoS Genet 11: e1005030. doi:10.1371/journal.pgen.1005030
Unckless, RL, SM Rottschaefer and BP Lazzaro. 2015. A genome-wide association study for nutritional indices in Drosophila. Genes, Genomes and Genetics 5:417-425. doi: 10.1534/g3.114.016477.
Unckless, RL, AM Larracuente and AG Clark. 2015. Sex-ratio meiotic drive and Y-linked resistance in Drosophila affinis. Genetics 199:831-840. doi:10.1534/genetics.114.173948.
2014
Orr, HA and RL Unckless. 2014. The population genetics of evolutionary rescue. PLoS Genetics 10(8): e104551.
Unckless, RL and AG Clark. 2014. Sex-ratio meiotic drive and interspecific competition. Journal of Evolutionary Biology 27(8): 1513-1521.
Prior to 2014
Unckless, RL and J Jaenike. 2012. Maintenance of a male-killing Wolbachia in Drosophila innubila by male-killing dependent and male-killing independent mechanisms. Evolution 66(3):678-689.
Unckless, RL. 2011. The potential role of the X chromosome in the emergence of male-killing from mutualistic endosymbionts. Journal of Theoretical Biology 291: 99-104.
Unckless, RL. 2011. A DNA virus of Drosophila. PLoS ONE 6: e26564.
Jaenike J, RL Unckless, SN Cockburn, LM Boelio, and SJ Perlman. 2010. Adaptive evolution via symbiosis: recent spread of a defensive symbiont in Drosophila. Science 329: 212-215.
Unckless, RL and HA Orr. 2009. The population genetics of adaptation: multiple substitutions on a smooth fitness landscape. Genetics 183: 1079-1086.
Jaenike J, JK Stahlhut, LM Boelio and RL Unckless. 2009. Association between Wolbachia and Spiroplasma within Drosophila neotestacea: an emerging symbiotic mutualism. Molecular Ecology 19: 414-425.
Unckless, RL and JK Herren. 2009. Population genetics of sexually antagonistic mitochondrial mutants under inbreeding. Journal of Theoretical Biology 260: 132-136.
Unckless, RL, LM Boelio, JK Herren and J Jaenike. 2009. Wolbachia as populations within individual insects: causes and consequences of density variation in natural populations. Proceedings of the Royal Society B 276: 2805-2811.
Unckless, RL, LM Boelio, C Cornish and KA Dyer. 2008. Isolation and characterization of 30 polymorphic microsatellite loci from the mycophagous fly Drosophila innubila. Molecular Ecology Research 8: 939-942.
Unckless, RL and HA Orr. 2009. Dobzhansky-Muller incompatibilities and adaptation to a shared environment. Heredity 102: 214-217.
Orr, HA and RL Unckless. 2008. Population extinction and the genetics of adaptation. American Naturalist 172: 160-169.
Unckless, RL and J Makarewicz. 2007. The impact of nutrient loading from Canada Geese (Branta canadensis) on water quality, a mesocosm approach. Hydrobiologia 586: 391-401.